Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice

Ying Zhao; Flora Ling; Hong-Cheng Wang; Xiao-Hong Sun

doi:10.1371/journal.pone.0055552

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Open Access

Peer-reviewed

Research Article

Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice

Ying Zhao,

Affiliation Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
⨯
Flora Ling,

Affiliations Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Hong-Cheng Wang,

Affiliation Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
⨯
Xiao-Hong Sun

* E-mail: sunx@omrf.org

Affiliations Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯

Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice

Ying Zhao,
Flora Ling,
Hong-Cheng Wang,
Xiao-Hong Sun

Published: February 1, 2013
https://doi.org/10.1371/journal.pone.0055552

About the Authors

Ying Zhao

Affiliation Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Flora Ling

Affiliations Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Hong-Cheng Wang

Affiliation Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Xiao-Hong Sun

* E-mail: sunx@omrf.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ XHS. Performed the experiments: YZ FL HCW. Analyzed the data: YZ FL HCW XHS. Wrote the paper: YZ FL HCW XHS.

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Hematopoietic stem cells
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Bone marrow cells
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Cytokines
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Inflammation
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Bone marrow transplantation
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Cytokine therapy
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Cell staining
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Bromodeoxyuridine labeling
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