About the Authors

Jon B. Toledo

Affiliation Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Xiao Da

Affiliation Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Priyanka Bhatt

Affiliation Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

David A. Wolk

Affiliation Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Steven E. Arnold

Affiliation Penn Memory Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Leslie M. Shaw

Affiliation Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

John Q. Trojanowski

Affiliation Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Christos Davatzikos

christos@rad.upenn.edu

Affiliation Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The disclosed conflicts of interests and funding sources do not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Performed the experiments: XD PB CD. Conceived and designed the experiments: JBT XD PB DAW SEA LMS JQT CD. Analyzed the data: JBT XD. Contributed reagents/materials/analysis tools: JBT XD CD. Wrote the paper: JBT XD PB DAW SEA LMS JQT CD.