About the Authors

Patrick M. McDonough

pmcdonough@valasciences.com

Affiliation Vala Sciences Inc, San Diego, California, United States of America

Dominique Maciejewski-Lenoir

Contributed equally to this work with: Dominique Maciejewski-Lenoir, Sean M. Hartig

Affiliation Vala Sciences Inc, San Diego, California, United States of America

Sean M. Hartig

Contributed equally to this work with: Dominique Maciejewski-Lenoir, Sean M. Hartig

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Rita A. Hanna

Affiliation Vala Sciences Inc, San Diego, California, United States of America

Ross Whittaker

Affiliation Vala Sciences Inc, San Diego, California, United States of America

Andrew Heisel

Affiliation Vala Sciences Inc, San Diego, California, United States of America

James B. Nicoll

Affiliation Zen-Bio, Inc, Research Triangle Park, North Carolina, United States of America

Benjamin M. Buehrer

Affiliation Zen-Bio, Inc, Research Triangle Park, North Carolina, United States of America

Kurt Christensen

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Maureen G. Mancini

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Michael A. Mancini

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Dean P. Edwards

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Jeffrey H. Price

Affiliations Vala Sciences Inc, San Diego, California, United States of America, Signal Transduction Program, The Sanford-Burnham Institute for Medical Research, La Jolla, California, United States of America

Competing Interests

The authors P. M. McDonough, R. Whittaker, A. Heisel, and J. H. Price are employees of Vala Sciences Inc. P. M. McDonough and J. H. Price are also stock-holders in Vala Sciences Inc. D. Maciejewski-Lenoir volunteered for Vala Sciences Inc for this project. J. B. Nicoll and B. M. Buehrer are employees of Zen-Bio, Inc. Reagents and software referred to in this paper are available from Vala Sciences Inc as commercial products. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DM-L SMH RW AH BMB MAM JHP PMM. Performed the experiments: DM-L SMH RW AH JBN RAH KC PMM. Analyzed the data: SMH RW MAM JHP PMM. Contributed reagents/materials/analysis tools: JBN BMB MGM DPE, JHP. Wrote the paper: DM-L SMH PMM.