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Research Article

Horizontal Transmission of Malignancy: In-Vivo Fusion of Human Lymphomas with Hamster Stroma Produces Tumors Retaining Human Genes and Lymphoid Pathology

  • David M. Goldenberg mail,

    dmg.gscancer@att.net

    Affiliation: Center for Molecular Medicine and Immunology, Garden State Cancer Center, Morris Plains, New Jersey, United States of America

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  • David V. Gold,

    Affiliation: Center for Molecular Medicine and Immunology, Garden State Cancer Center, Morris Plains, New Jersey, United States of America

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  • Meiyu Loo,

    Affiliation: Immunomedics, Inc., Morris Plains, New Jersey, United States of America

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  • Donglin Liu,

    Affiliation: Immunomedics, Inc., Morris Plains, New Jersey, United States of America

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  • Chien-Hsing Chang,

    Affiliation: Immunomedics, Inc., Morris Plains, New Jersey, United States of America

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  • Elaine S. Jaffe

    Affiliation: Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, United States of America

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  • Published: February 06, 2013
  • DOI: 10.1371/journal.pone.0055324

About the Authors

David M. Goldenberg, David V. Gold
Center for Molecular Medicine and Immunology, Garden State Cancer Center, Morris Plains, New Jersey, United States of America
Meiyu Loo, Donglin Liu, Chien-Hsing Chang
Immunomedics, Inc., Morris Plains, New Jersey, United States of America
Elaine S. Jaffe
Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, United States of America

Corresponding Author

Email: dmg.gscancer@att.net

Competing Interests

The authors have the following interest: Meiyu Loo, Donglin Liu and Chien-Hsing Chang are employed by Immunomedics, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Reviewed and Edited the paper: DVG CHC ESJ. Conceived and designed the experiments: DMG. Performed the experiments: DVG ML DL CHC ESJ. Analyzed the data: DMG DVG ML DL CHC ESJ. Wrote the paper: DMG.