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Research Article

Increased HIV Incidence in Men Who Have Sex with Men Despite High Levels of ART-Induced Viral Suppression: Analysis of an Extensively Documented Epidemic

  • Andrew N. Phillips mail,

    andrew.phillips@ucl.ac.uk

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Valentina Cambiano,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Fumiyo Nakagawa,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Alison E. Brown,

    Affiliation: Health Protection Agency, London, United Kingdom

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  • Fiona Lampe,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Alison Rodger,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Alec Miners,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Jonathan Elford,

    Affiliation: City University, London, United Kingdom

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  • Graham Hart,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Anne M. Johnson,

    Affiliation: Research Department of Infection & Population Health, UCL, London, United Kingdom

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  • Jens Lundgren,

    Affiliation: Copenhagen University Hospital/Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark

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  • Valerie C. Delpech

    Affiliation: Health Protection Agency, London, United Kingdom

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  • Published: February 15, 2013
  • DOI: 10.1371/journal.pone.0055312

About the Authors

Andrew N. Phillips, Valentina Cambiano, Fumiyo Nakagawa, Fiona Lampe, Alison Rodger, Graham Hart, Anne M. Johnson
Research Department of Infection & Population Health, UCL, London, United Kingdom
Alison E. Brown, Valerie C. Delpech
Health Protection Agency, London, United Kingdom
Alec Miners
London School of Hygiene and Tropical Medicine, London, United Kingdom
Jonathan Elford
City University, London, United Kingdom
Jens Lundgren
Copenhagen University Hospital/Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark

Corresponding Author

Email: andrew.phillips@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Contributed to the formulation of the research questions, had critical input into interpretation of results, and had substantial input into the drafting of the manuscript: AP VC FN AB FL AR AM JE GH AJ JL VD. Led on collection of the HIV surveillance data used in the analysis: VD AB. Worked on development and programming of the HIV Synthesis model: AP VC FN. Performed the modelling analysis: AP. Conceived and designed the experiments: AP VC FN AM AB FL AR JE GH AJ VD JL. Performed the experiments: AP VC FN. Analyzed the data: AP VC. Wrote the paper: AP VC FN AM AB FL AR JE GH AJ VD JL.