About the Authors

Maral Tajerian

Contributed equally to this work with: Maral Tajerian, Sebastian Alvarado

Affiliations Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

Sebastian Alvarado

Contributed equally to this work with: Maral Tajerian, Sebastian Alvarado

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

Magali Millecamps

Affiliations Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

Pascal Vachon

Affiliation University of Montreal, Department of Veterinary Biomedicine, St-Hyacinthe, Quebec, Canada

Cecilia Crosby

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

M. Catherine Bushnell

Affiliations Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Anesthesiology, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

Moshe Szyf

moshe.szyf@mcgill.ca (MS); laura.s.stone@mcgill.ca (LS)

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada

Laura S. Stone

moshe.szyf@mcgill.ca (MS); laura.s.stone@mcgill.ca (LS)

Affiliations Alan Edwards Centre for Research on Pain, Faculty of Medicine, McGill University, Montreal, Canada, Department of Anesthesiology, McGill University, Montreal, Canada, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada

Competing Interests

The authors wish to declare that this study was funded, in part, from a commercial funder (Eli Lilly Canada Inc). The funding was in the form of an unrestricted research grant and the funder has no influence on the content. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MT SA MM PV MCB MS LSS. Performed the experiments: MT SA MM PV CC. Analyzed the data: MT SA MM MS LSS. Wrote the paper: MT MS LSS.