About the Authors

Zsolt Czimmerer

Affiliation Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Julianna Hulvely

Affiliation Astrid Research Ltd, Debrecen, Hungary

Zoltan Simandi

Affiliation Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Eva Varallyay

Affiliation Plant Developmental Biology Group, Agricultural Biotechnology Center, Gödöllő, Hungary

Zoltan Havelda

Affiliation Plant Developmental Biology Group, Agricultural Biotechnology Center, Gödöllő, Hungary

Erzsebet Szabo

Affiliation Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Attila Varga

Affiliation Astrid Research Ltd, Debrecen, Hungary

Balazs Dezso

Affiliation Institute of Pathology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Maria Balogh

Affiliation Center for Clinical Genomics and Personalized Medicine, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Attila Horvath

Affiliations Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary, Astrid Research Ltd, Debrecen, Hungary

Balint Domokos

Affiliation Astrid Research Ltd, Debrecen, Hungary

Zsolt Torok

Affiliations Astrid Research Ltd, Debrecen, Hungary, Department of Computer Graphics and Image Processing, University of Debrecen Centre of Arts, Humanities and Sciences, Debrecen, Hungary

Laszlo Nagy

Affiliations Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary, MTA-DE “Lendulet” Immunogenomics Research Group, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary

Balint L. Balint

lbalint@med.unideb.hu

Affiliations Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary, Center for Clinical Genomics and Personalized Medicine, Research Center for Molecular Medicine, University of Debrecen Medical and Health Science Center, Debrecen, Hungary, UD-Genomed Ltd, Debrecen, Hungary

Competing Interests

At the time of preparing the manuscript, JH, AV and AH were employed by Astrid Research Ltd. ZT is an owner of Astrid Research Ltd. B. Domokos is currently employed by Astrid Research Ltd. BLB and LN are owners of UDGenomed Ltd. At the time of preparing the manuscript, BLB was a scientific consultant at Roche Hungary. Some of the reagents for these measurements were provided by Roche Hungary. Roche is now marketing an alternative miRNA measurement technology and has discontinued its collaboration in this field with the authors of the manuscript. None of these affiliations affect the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BLB LN ZH ZC ZT. Performed the experiments: ZC JH EV ES B. Dezso ZS AH AV MB. Analyzed the data: ZC ZT EV ZH ES BLB B. Domokos. Contributed reagents/materials/analysis tools: LN ZH ZT. Wrote the paper: ZC BLB.