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Research Article

Thermally Targeted Delivery of a c-Myc Inhibitory Polypeptide Inhibits Tumor Progression and Extends Survival in a Rat Glioma Model

  • Gene L. Bidwell III,

    Affiliations: Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Eddie Perkins,

    Affiliations: Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Joshua Hughes,

    Affiliation: Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Majid Khan,

    Affiliations: Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Department of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Judy R. James,

    Affiliation: Department of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Drazen Raucher mail

    draucher@umc.edu

    Affiliations: Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Published: January 25, 2013
  • DOI: 10.1371/journal.pone.0055104

About the Authors

Gene L. Bidwell III, Majid Khan
Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Gene L. Bidwell III, Eddie Perkins, Drazen Raucher
Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Eddie Perkins, Joshua Hughes
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Eddie Perkins
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Majid Khan, Judy R. James
Department of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Drazen Raucher
Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Corresponding Author

Email: draucher@umc.edu

Competing Interests

GLB is a paid consultant for Thermally Targeted Therapeutics. EP is a paid consultant for Thermally Targeted Therapeutics. DR is President of Thermally Targeted Therapeutics. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GLB EP DR. Performed the experiments: GLB EP JH. Analyzed the data: GLB MK JRJ. Wrote the paper: GLB EP JRJ DR.