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Research Article

Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume

  • David Habart,

    Affiliation: Roon Research Center for Arteriosclerosis and Thrombosis, The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

    Current address: Islet Transplant Laboratory, Diabetes Centre, Institute of Clinical and Experimental Medicine, Prague, Czech Republic

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  • Yann Cheli,

    Affiliation: Roon Research Center for Arteriosclerosis and Thrombosis, The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

    Current address: INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Equipe 1, Biology and Pathologies of Melanocytes, Nice, France

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  • Diane J. Nugent,

    Affiliation: Hematology Research, CHOC Children's Hospital, Orange, California, United States of America

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  • Zaverio M. Ruggeri,

    Affiliation: Roon Research Center for Arteriosclerosis and Thrombosis, The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

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  • Thomas J. Kunicki mail

    tkunicki@choc.org

    Affiliations: Roon Research Center for Arteriosclerosis and Thrombosis, The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America, Hematology Research, CHOC Children's Hospital, Orange, California, United States of America

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.pone.0055094

About the Authors

David Habart, Yann Cheli, Zaverio M. Ruggeri, Thomas J. Kunicki
Roon Research Center for Arteriosclerosis and Thrombosis, The Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
Diane J. Nugent, Thomas J. Kunicki
Hematology Research, CHOC Children's Hospital, Orange, California, United States of America

Corresponding Author

Email: tkunicki@choc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DH TJK. Performed the experiments: DH YC TJK. Analyzed the data: DH YC DJN TJK. Contributed reagents/materials/analysis tools: DJN ZMR TJK. Wrote the paper: DH TJK.