Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation

Yingdong Zhu; Renaud F. Warin; Dominique N. Soroka; Huadong Chen; Shengmin Sang

doi:10.1371/journal.pone.0054677

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Open Access

Peer-reviewed

Research Article

Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation

Yingdong Zhu,

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
⨯
Renaud F. Warin ,

Contributed equally to this work with: Renaud F. Warin, Dominique N. Soroka

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
⨯
Dominique N. Soroka ,

Contributed equally to this work with: Renaud F. Warin, Dominique N. Soroka

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
⨯
Huadong Chen,

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
⨯
Shengmin Sang

* E-mail: ssang@ncat.edu

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
⨯

Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation

Yingdong Zhu,
Renaud F. Warin,
Dominique N. Soroka,
Huadong Chen,
Shengmin Sang

Published: January 30, 2013
https://doi.org/10.1371/journal.pone.0054677

About the Authors

Yingdong Zhu

Affiliation Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America

Renaud F. Warin

Contributed equally to this work with: Renaud F. Warin, Dominique N. Soroka

Dominique N. Soroka

Contributed equally to this work with: Renaud F. Warin, Dominique N. Soroka

Huadong Chen

Shengmin Sang

* E-mail: ssang@ncat.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS. Performed the experiments: YZ RFW DS HC. Analyzed the data: YZ RFW DS HC SS. Wrote the paper: YZ RFW DS HC SS.

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Cell metabolism
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Lung and intrathoracic tumors
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Apoptosis
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Metabolites
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Chemical synthesis
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Colorectal cancer
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Cancer treatment
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Toxicity
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