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Research Article

A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy

  • Camilla S. Bruun mail,

    cvb@sund.ku.dk (CSB); mf@sund.ku.dk (MF)

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Karin H. Jäderlund,

    Affiliation: Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • Mette Berendt,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Kristine B. Jensen,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Eva H. Spodsberg,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Hanne Gredal,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • G. Diane Shelton,

    Affiliation: Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

    X
  • James R. Mickelson,

    Affiliation: College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America

    X
  • Katie M. Minor,

    Affiliation: College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America

    X
  • Hannes Lohi,

    Affiliation: Department of Veterinary Biosciences, Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsen Research Center, Helsinki, Finland

    X
  • Inge Bjerkås,

    Affiliation: Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • Øyvind Stigen,

    Affiliation: Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • Arild Espenes,

    Affiliation: Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • Cecilia Rohdin,

    Affiliation: University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden

    X
  • Rebecca Edlund,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Jennie Ohlsson,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Sigitas Cizinauskas,

    Affiliation: Department of Veterinary Biosciences, Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsen Research Center, Helsinki, Finland

    X
  • Páll S. Leifsson,

    Affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Cord Drögemüller,

    Affiliation: Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    X
  • Lars Moe,

    Affiliation: Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway

    X
  • Susanna Cirera,

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Merete Fredholm mail

    cvb@sund.ku.dk (CSB); mf@sund.ku.dk (MF)

    Affiliation: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark

    X
  • Published: February 05, 2013
  • DOI: 10.1371/journal.pone.0054547

About the Authors

Camilla S. Bruun, Mette Berendt, Kristine B. Jensen, Eva H. Spodsberg, Hanne Gredal, Rebecca Edlund, Jennie Ohlsson, Susanna Cirera, Merete Fredholm
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
Karin H. Jäderlund, Øyvind Stigen, Lars Moe
Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
G. Diane Shelton
Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America
James R. Mickelson, Katie M. Minor
College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America
Hannes Lohi, Sigitas Cizinauskas
Department of Veterinary Biosciences, Research Programs Unit, Molecular Medicine, University of Helsinki and Folkhälsen Research Center, Helsinki, Finland
Inge Bjerkås, Arild Espenes
Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
Cecilia Rohdin
University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden
Páll S. Leifsson
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
Cord Drögemüller
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: S. Cirera MF CSB MB. Performed the experiments: CSB KHJ MB KBJ EHS HG GDS JRM KMM HL IB ØS AE CR RE JO S. Cirera PSL CD LM MF. Analyzed the data: CSB GDS RE JO PSL S. Cirera MF. Contributed reagents/materials/analysis tools: MB HG JRM KMM HL CR S. Cizinauskas LM. Wrote the paper: CSB KHJ MB GDS JRM MF.