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Research Article

A Lower Degree of PBMC L1 Methylation Is Associated with Excess Body Weight and Higher HOMA-IR in the Presence of Lower Concentrations of Plasma Folate

  • Chandrika J. Piyathilake mail,

    piyathic@uab.edu

    Affiliation: The Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, United States of America

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  • Suguna Badiga,

    Affiliation: The Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, United States of America

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  • Ronald D. Alvarez,

    Affiliation: Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Edward E. Partridge,

    Affiliation: Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Gary L. Johanning

    Affiliation: Department of Veterinary Sciences, The University of Texas MD Anderson Cancer Center, Smithville, Texas, United States of America

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.pone.0054544

About the Authors

Chandrika J. Piyathilake, Suguna Badiga
The Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, United States of America
Ronald D. Alvarez
Department of Obstetrics & Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Edward E. Partridge
Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Gary L. Johanning
Department of Veterinary Sciences, The University of Texas MD Anderson Cancer Center, Smithville, Texas, United States of America

Corresponding Author

Email: piyathic@uab.edu

Competing Interests

The authors have declared that no competing interest exists.

Author Contributions

Critically revising the article: GLJ RDA EEP. Conceived and designed the experiments: CJP. Analyzed the data: CJP SB. Wrote the paper: CJP.