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Research Article

Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography

  • Linbo Liu,

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Kengyeh K. Chu,

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Grace H. Houser,

    Affiliation: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Bradford J. Diephuis,

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Yao Li,

    Affiliation: Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Eric J. Wilsterman,

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Suresh Shastry,

    Affiliation: Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Gregory Dierksen,

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Susan E. Birket,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Marina Mazur,

    Affiliation: Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Suzanne Byan-Parker,

    Affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • William E. Grizzle,

    Affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Eric J. Sorscher,

    Affiliations: Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Steven M. Rowe equal contributor mail,

    equal contributor Contributed equally to this work with: Steven M. Rowe, Guillermo J. Tearney

    smrowe@uab.edu (SMR); gtearney@partners.org (GJT)

    Affiliations: Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Guillermo J. Tearney equal contributor mail

    equal contributor Contributed equally to this work with: Steven M. Rowe, Guillermo J. Tearney

    smrowe@uab.edu (SMR); gtearney@partners.org (GJT)

    Affiliations: Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Published: January 23, 2013
  • DOI: 10.1371/journal.pone.0054473

About the Authors

Linbo Liu, Kengyeh K. Chu, Bradford J. Diephuis, Eric J. Wilsterman, Gregory Dierksen, Guillermo J. Tearney
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Linbo Liu, Kengyeh K. Chu, Eric J. Wilsterman, Gregory Dierksen
Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Grace H. Houser
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Bradford J. Diephuis, Guillermo J. Tearney
Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
Bradford J. Diephuis
Harvard Medical School, Boston, Massachusetts, United States of America
Yao Li, Suresh Shastry, Marina Mazur, Eric J. Sorscher, Steven M. Rowe
Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Susan E. Birket, Eric J. Sorscher, Steven M. Rowe
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Suzanne Byan-Parker, William E. Grizzle
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Guillermo J. Tearney
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The following authors declare that they have filed a patent application related to the application of μOCT technology to airways: Linbo Liu, Kengyeh K. Chu, Grace H. Houser, Bradford J. Diephuis, Eric J. Wilsterman, Gregory Dierksen, Eric J. Sorscher, Steven M. Rowe, and Guillermo J. Tearney. The application serial number is PCT/US12/52553, entitled “Method for functional investigation of respiratory airways and other ciliated tissues using μOCT,” filed August 27, 2012. No financial benefit has yet been derived from this application by any author. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GJT SMR LL EJS. Performed the experiments: LL KKC GHH BJD YL EJW SS GD SEB MM SBP. Analyzed the data: GJT SMR LL KKC GHH BJD YL EJW SS GD SEB WEG. Contributed reagents/materials/analysis tools: GJT SMR LL KKC GD MM SBP WEG EJS. Wrote the paper: GJT SMR LL KKC.