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Research Article

Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

  • Edward H. Schuchman,

    Affiliation: Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Yi Ge,

    Affiliation: Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Alon Lai,

    Affiliation: Orthopedics, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Yury Borisov,

    Affiliation: Orthopedics, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Meghan Faillace,

    Affiliation: Orthopedics, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Efrat Eliyahu,

    Affiliation: Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Xingxuan He,

    Affiliation: Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • James Iatridis,

    Affiliation: Orthopedics, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Helen Vlassara,

    Affiliation: Medicine and Geriatrics and Palliative Care, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Gary Striker,

    Affiliation: Medicine and Geriatrics and Palliative Care, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Calogera M. Simonaro mail

    Calogera.simonaro@mssm.edu

    Affiliation: Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.pone.0054459

About the Authors

Edward H. Schuchman, Yi Ge, Efrat Eliyahu, Xingxuan He, Calogera M. Simonaro
Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
Alon Lai, Yury Borisov, Meghan Faillace, James Iatridis
Orthopedics, Mount Sinai School of Medicine, New York, New York, United States of America
Helen Vlassara, Gary Striker
Medicine and Geriatrics and Palliative Care, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: Calogera.simonaro@mssm.edu

Competing Interests

EHS, GS, HV, and CMS are co-inventors on a patent application describing PPS therapy for the MPS diseases. A patent application (61/569,452) has been submitted for the use of pentosoan polysulfate in the MPS disorders. If this patent is licensed, it could generate royalty income for Mount Sinai and the inventors. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EHS CMS. Performed the experiments: YG AL MF EE XH CMS. Analyzed the data: EHS YB MF JI GS HV CMS. Contributed reagents/materials/analysis tools: GS HV. Wrote the paper: EHS CMS.