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Research Article

Prospective Surveillance for Cardiac Adverse Events in Healthy Adults Receiving Modified Vaccinia Ankara Vaccines: A Systematic Review

  • Marnie L. Elizaga,

    Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Sandhya Vasan,

    Affiliation: Aaron Diamond AIDS Research Center, New York, New York, United States of America

    Current address: United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

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  • Mary A. Marovich,

    Affiliation: United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America

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  • Alicia H. Sato,

    Affiliation: Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Dale N. Lawrence,

    Affiliation: Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Bernard R. Chaitman,

    Affiliation: Division of Cardiology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • Sharon E. Frey,

    Affiliation: Clinical Research Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael C. Keefer, for the MVA Cardiac Safety Working Group mail

    Michael_Keefer@URMC.Rochester.edu

    Affiliation: University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

    Membership of the MVA Cardiac Safety Working Group is provided in the Acknowledgements.

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  • Published: January 17, 2013
  • DOI: 10.1371/journal.pone.0054407

About the Authors

Marnie L. Elizaga
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Sandhya Vasan
Aaron Diamond AIDS Research Center, New York, New York, United States of America
Mary A. Marovich
United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America
Alicia H. Sato
Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Dale N. Lawrence
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Bernard R. Chaitman
Division of Cardiology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
Sharon E. Frey
Clinical Research Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America
Michael C. Keefer
University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

Corresponding Author

Email: Michael_Keefer@URMC.Rochester.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLE SV MAM DNL SEF MCK. Performed the experiments: MLE SV MAM BRC SEF MCK. Analyzed the data: AHS MLE SV. Contributed reagents/materials/analysis tools: BRC MLE DNL. Wrote the paper: MLE SV MAM AHS DNL BRC SEF MCK.