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Research Article

DNA Methylation in the Malignant Transformation of Meningiomas

  • Fan Gao,

    Affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Lingling Shi,

    Affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Jonathan Russin,

    Affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Liyun Zeng,

    Affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

    X
  • Xiao Chang,

    Affiliation: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Shuhan He,

    Affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Thomas C. Chen,

    Affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Steven L. Giannotta,

    Affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Daniel J. Weisenberger,

    Affiliation: USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Gabriel Zada,

    Affiliation: Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • William J. Mack mail,

    mackw@usc.edu (WJM); kaiwang@usc.edu (KW)

    Affiliations: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America, Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

    X
  • Kai Wang mail

    mackw@usc.edu (WJM); kaiwang@usc.edu (KW)

    Affiliations: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America, Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, United States of America, Division of Bioinformatics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

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  • Published: January 22, 2013
  • DOI: 10.1371/journal.pone.0054114

About the Authors

Fan Gao, Lingling Shi, Liyun Zeng, Xiao Chang, William J. Mack, Kai Wang
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Jonathan Russin, Shuhan He, Thomas C. Chen, Steven L. Giannotta, Gabriel Zada, William J. Mack
Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Daniel J. Weisenberger
USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Kai Wang
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Kai Wang
Division of Bioinformatics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WJM KW. Performed the experiments: FG LS LZ DJW. Analyzed the data: FG. Contributed reagents/materials/analysis tools: JR XC SH TCC SLG DJW GZ. Wrote the paper: FG DJW WJM KW.