About the Authors

Jianru Shi

Contributed equally to this work with: Jianru Shi, Bingbing Jiang

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Bingbing Jiang

Contributed equally to this work with: Jianru Shi, Bingbing Jiang

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Yiling Qiu

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jian Guan

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Mohit Jain

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Xin Cao

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Michael Bauer

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Lihe Su

Affiliation Protein Biochemistry Department, Biogen Idec, Inc, Cambridge, Massachusetts, United States of America

Linda C. Burkly

Affiliation Immunology Department, Biogen Idec, Inc, Cambridge, Massachusetts, United States of America

Teresa C. Leone

Affiliation Cardiovascular pathobiology program, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, Florida, United States of America

Daniel P. Kelly

Affiliation Cardiovascular pathobiology program, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, Florida, United States of America

Ronglih Liao

rliao@rics.bwh.harvard.edu

Affiliation Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

J.S., B.J., Y.Q., J.G., M.J., X.C., M.B., D.P.K. and R.L. have declared no competing interests for this work. L.S. and L.C.B. are employees of Biogen-IDEC, and the authors confirm that this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Contributed to data interpretation and scientific discussion: LCB DPK MJ. Conceived and designed the experiments: JS BJ MJ RL. Performed the experiments: JS JG MB YQ XC. Analyzed the data: JS BJ. Contributed reagents/materials/analysis tools: LS LCB TCL DPK. Wrote the paper: JS BJ MJ RL.