About the Authors

Manish A. Shah

mas9313@med.cornell.edu

Affiliation The Weill Cornell Medical College/New York–Presbyterian Hospital, New York, New York, United States of America

Zev A. Wainberg

Affiliation University of California Los Angeles, Los Angeles, California, United States of America

Daniel V. T. Catenacci

Affiliation University of Chicago, Chicago, Illinois, United States of America

Howard S. Hochster

Affiliation Yale University, New Haven, Connecticut, United States of America

James Ford

Affiliation Stanford University, Stanford, California, United States of America

Pamela Kunz

Affiliation Stanford University, Stanford, California, United States of America

Fa-Chyi Lee

Affiliation University of New Mexico, Albuquerque, New Mexico, United States of America

Howard Kallender

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Fabiola Cecchi

Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Daniel C. Rabe

Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Harold Keer

Affiliation Exelixis, South San Francisco, California, United States of America

Anne-Marie Martin

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Yuan Liu

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Robert Gagnon

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Peter Bonate

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Li Liu

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Tona Gilmer

Affiliation GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Donald P. Bottaro

Affiliation Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

Competing Interests

Dr. Kallender, Dr. Martin, Dr. Y. Liu, Dr. Gagnon Dr. L. Liu, Dr. Gilmer are employees of, and have equity interest in GlaxoSmithKline. Dr. Keer is an employee of FivePrime Therapeutics Inc. with equity interest in Exelixis. Editorial support in the form of development of draft outline, development of manuscript first draft, assembling tables and figures, collating author comments, copyediting and referencing was provided by Ann Sherwood, PhD of CONNEXION Healthcare, Newtown, PA, and by MediTech Media, Manchester, UK, and was funded by GlaxoSmithKline. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Final approval of manuscript: MAS ZAW DC HH JF PK FCL H. Kallender FC DCR H. Keer AMM YL RG PB LL TG DPB. Conceived and designed the experiments: H. Kallender MAS DPB H. Keer. Performed the experiments: MAS ZAW DC HH JF PK FCL DPB PB LL TG. Analyzed the data: DPB DCR FC MAS H. Kallender AMM YL RG PB LL TG. Contributed reagents/materials/analysis tools: DPB H. Kallender MAS. Wrote the paper: MAS H. Kallender DPB.