About the Authors

Elizabeth G. Holliday

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Liz.Holliday@newcastle.edu.au

Affiliation Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

Albert V. Smith

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Belinda K. Cornes

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Gabriëlle H. S. Buitendijk

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Richard A. Jensen

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

Xueling Sim

Contributed equally to this work with: Elizabeth G. Holliday, Albert V. Smith, Belinda K. Cornes, Gabriëlle H. S. Buitendijk, Richard A. Jensen, Xueling Sim

Affiliations Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Thor Aspelund

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Tin Aung

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Paul N. Baird

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Eric Boerwinkle

Affiliation Human Genetics Center and Human Genome Sequencing Center, University of Texas and Baylor College of Medicine, Houston, Texas, United States of America

Ching Yu Cheng

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore

Cornelia M. van Duijn

Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Gudny Eiriksdottir

Affiliation Icelandic Heart Association, Kopavogur, Iceland

Vilmundur Gudnason

Affiliations Icelandic Heart Association, Kopavogur, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Tamara Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Alex W. Hewitt

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Michael Inouye

Affiliation Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia

Fridbert Jonasson

Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland

Barbara E. K. Klein

Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

Lenore Launer

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Xiaohui Li

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Gerald Liew

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Thomas Lumley

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Statistics, University of Auckland, Auckland, New Zealand

Patrick McElduff

Affiliation Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

Barbara McKnight

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Paul Mitchell

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Bruce M. Psaty

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

Elena Rochtchina

Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Rodney J. Scott

Affiliation School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia and Hunter Medical Research Institute, and Hunter Area Pathology Service, Newcastle, New South Wales, Australia

Wanting Tay

Affiliation Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Kent Taylor

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Yik Ying Teo

Affiliation Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

André G. Uitterlinden

Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands

Ananth Viswanathan

Affiliation Moorfields Eye Hospital, London, United Kingdom

Sophia Xie

Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia

Wellcome Trust Case Control Consortium 2

‡ Membership of the Wellcome Trust Case Control Consortium 2 is listed in Table S3 in File S2.

Johannes R. Vingerling

These authors also contributed equally to this work.

Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

Caroline C. W. Klaver

These authors also contributed equally to this work.

Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

E. Shyong Tai

These authors also contributed equally to this work.

Affiliations Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore, Department of Medicine, National University of Singapore, Singapore, Singapore, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

David Siscovick

These authors also contributed equally to this work.

Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Ronald Klein

These authors also contributed equally to this work.

Affiliation Department of Ophthalmology and Visual Science, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

Mary Frances Cotch

These authors also contributed equally to this work.

Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America

Tien Y. Wong

These authors also contributed equally to this work.

Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Department of Ophthalmology, National University of Singapore, Singapore, Singapore

John Attia

These authors also contributed equally to this work.

Affiliations Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia, Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, Newcastle, New South Wales, Australia

Jie Jin Wang

These authors also contributed equally to this work.

Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Revised the article for important intellectual content: EGH AVS BKC GHSB RAJ XS T. Aspelund T. Aung PNB EB CYC CMD GE VG TH AWH MI FJ BEKK LL XL GL TL P. McElduff BM PM BMP ER JIR RJS WT KT YYT AGU AV SX WTCCC2 JRV CCWK EST DS RK MFC TYW JA JJW. Approved final version to be published: EGH AVS BKC GHSB RAJ XS T. Aspelund T. Aung PNB EB CYC CMD GE VG TH AWH MI FJ BEKK LL XL GL TL P. McElduff BM P. Mitchell BMP ER JIR RJS WT KT YYT AGU AV SX WTCCC2 JRV CCWK EST DS RK MFC TYW JA JJW. Conceived and designed the experiments: JRV CCWK EST DS RK MFC TYW JA JJW. Performed the experiments: EGH AVS BKC GHSB RAJ XS. Analyzed the data: EGH AVS BKC GHSB RAJ XS. Contributed reagents/materials/analysis tools: T. Aspelund T. Aung PNB EB CYC CMD GE VG TH AWH MI FJ BEKK LL XL GL TL P. McElduff BM P. Mitchell BMP ER JIR RJS WT KT YYT AGU AV SX WTCCC2. Wrote the paper: EGH JA JJW.