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Research Article

In Vivo Targeting of ADAM9 Gene Expression Using Lentivirus-Delivered shRNA Suppresses Prostate Cancer Growth by Regulating REG4 Dependent Cell Cycle Progression

  • Che-Ming Liu equal contributor,

    equal contributor Contributed equally to this work with: Che-Ming Liu, Chia-Ling Hsieh

    Affiliation: Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan, ROC

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  • Chia-Ling Hsieh equal contributor,

    equal contributor Contributed equally to this work with: Che-Ming Liu, Chia-Ling Hsieh

    Affiliations: Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC, Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC, Department of Biotechnology, Asia University, Wufeng, Taichung, Taiwan, ROC

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  • Yun-Chi He,

    Affiliation: Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC

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  • Sen-Jei Lo,

    Affiliation: Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC

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  • Ji-An Liang,

    Affiliation: Division of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, ROC

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  • Teng-Fu Hsieh,

    Affiliations: Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, ROC, Division of Urology, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan, ROC, Department of Urology, School of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan, ROC

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  • Sajni Josson,

    Affiliation: Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, United States of America

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  • Leland W. K. Chung,

    Affiliation: Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, United States of America

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  • Mien-Chie Hung,

    Affiliations: Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC, Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC, Department of Biotechnology, Asia University, Wufeng, Taichung, Taiwan, ROC, Department of Molecular and Cellular Oncology, M.D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America

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  • Shian-Ying Sung mail

    ssung@mail.cmu.edu.tw

    Affiliations: Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan, ROC, Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC, Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC

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  • Published: January 16, 2013
  • DOI: 10.1371/journal.pone.0053795

About the Authors

Che-Ming Liu, Shian-Ying Sung
Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan, ROC
Chia-Ling Hsieh, Yun-Chi He, Sen-Jei Lo, Mien-Chie Hung, Shian-Ying Sung
Graduate Institutes of Cancer Biology, China Medical University, Taichung, Taiwan, ROC
Teng-Fu Hsieh
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, ROC
Chia-Ling Hsieh, Mien-Chie Hung, Shian-Ying Sung
Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC
Ji-An Liang
Division of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, ROC
Teng-Fu Hsieh
Division of Urology, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan, ROC
Teng-Fu Hsieh
Department of Urology, School of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan, ROC
Sajni Josson, Leland W. K. Chung
Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, United States of America
Chia-Ling Hsieh, Mien-Chie Hung
Department of Biotechnology, Asia University, Wufeng, Taichung, Taiwan, ROC
Mien-Chie Hung
Department of Molecular and Cellular Oncology, M.D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America

Corresponding Author

Email: ssung@mail.cmu.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SYS. Performed the experiments: CML YCH SJL TFH SJ SYS. Analyzed the data: CLH SYS MCH. Contributed reagents/materials/analysis tools: MCH JAL SYS LWKC. Wrote the paper: SYS.