About the Authors

Stefan Balabanov

Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Division of Hematology, University Hospital Zürich, Zürich, Switzerland

Thomas Wilhelm

Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Department of Biochemistry, University Hospital Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

Simone Venz

Affiliations Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany, Interfacultary Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

Gunhild Keller

Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

Christian Scharf

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University of Greifswald, Greifswald, Germany

Heike Pospisil

Affiliation Bioinformatics, University of Applied Sciences Wildau, Wildau, Germany

Melanie Braig

Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

Christine Barett

Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

Carsten Bokemeyer

Affiliation Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany

Reinhard Walther

Affiliation Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany

Tim H. Brümmendorf

Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

Affiliations Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumor Zentrum (UCCH), University Hospital Eppendorf (UKE), Hamburg, Germany, Medizinische Klinik IV - Hämatologie und Onkologie, Universitätsklinikum Aachen (UKA) of the Rheinisch.-Westfälische Technische Hochschule Aachen, Aachen, Germany

Andreas Schuppert

Contributed equally to this work with: Tim H. Brümmendorf, Andreas Schuppert

schuppert@aices.rwth-aachen.de

Affiliation Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, Aachen, Germany

Competing Interests

THB received research support from Novartis and Bristol-Meyers Squibb. Furthermore THB participated in clinical trials investigating Imatinib, Nilotinib, Dasatinib and Danusertib in CML patients. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SB AS THB. Performed the experiments: SB TW SV CS MB C. Barett AS. Analyzed the data: SB SV CS HP AS. Wrote the paper: SB GK MB C. Bokemeyer RW AS THB.