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Research Article

Microevolution of the Chromosomal Region of Acute Disease Antigen A (adaA) in the Query (Q) Fever Agent Coxiella burnetii

  • Dimitrios Frangoulidis mail,

    DimitriosFrangoulidis@Bundeswehr.org

    Affiliation: Bundeswehr Institute of Microbiology, Munich, Germany

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  • Wolf D. Splettstoesser,

    Affiliation: Bundeswehr Institute of Microbiology, Munich, Germany

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  • Olfert Landt,

    Affiliation: TIB MOLBIOL GmbH, Berlin, Germany

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  • Jasmin Dehnhardt,

    Affiliation: TIB MOLBIOL GmbH, Berlin, Germany

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  • Klaus Henning,

    Affiliation: Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Wusterhausen, Germany

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  • Angela Hilbert,

    Affiliation: Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Wusterhausen, Germany

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  • Tilman Bauer,

    Affiliation: Freiburg, Germany

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  • Markus Antwerpen,

    Affiliation: Bundeswehr Institute of Microbiology, Munich, Germany

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  • Hermann Meyer,

    Affiliation: Bundeswehr Institute of Microbiology, Munich, Germany

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  • Mathias C. Walter equal contributor,

    equal contributor Contributed equally to this work with: Mathias C. Walter, Johannes K.-M. Knobloch

    Affiliations: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Genome-Oriented Bioinformatics, Center of Life and Food Science Weihenstephan, Technische Universität München, Freising, Germany

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  • Johannes K.-M. Knobloch equal contributor

    equal contributor Contributed equally to this work with: Mathias C. Walter, Johannes K.-M. Knobloch

    Affiliation: University of Lübeck, Institute for Medical Microbiology and Hygiene, Lübeck, Germany

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pone.0053440

About the Authors

Dimitrios Frangoulidis, Wolf D. Splettstoesser, Markus Antwerpen, Hermann Meyer
Bundeswehr Institute of Microbiology, Munich, Germany
Olfert Landt, Jasmin Dehnhardt
TIB MOLBIOL GmbH, Berlin, Germany
Klaus Henning, Angela Hilbert
Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Wusterhausen, Germany
Tilman Bauer
Freiburg, Germany
Mathias C. Walter
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Mathias C. Walter
Department of Genome-Oriented Bioinformatics, Center of Life and Food Science Weihenstephan, Technische Universität München, Freising, Germany
Johannes K.-M. Knobloch
University of Lübeck, Institute for Medical Microbiology and Hygiene, Lübeck, Germany

Corresponding Author

Email: DimitriosFrangoulidis@Bundeswehr.org

Competing Interests

The authors have the following interests. Olfert Landt and Jasmin Dehnhardt are employed by TIB MOLBIOL GmbH who produced some of the PCRs in this study. Sequencing analysis has been done in part at GATC, Constance, Germany. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: DF. Performed the experiments: JD JK MA OL. Analyzed the data: DF HM JK MA MW OL WS. Contributed reagents/materials/analysis tools: AH KH MW TB WS. Wrote the paper: DF JK MW OL.