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Research Article

[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts

  • Mette Munk Jensen mail,

    mettemj@sund.ku.dk

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Kamille Dumong Erichsen,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Camilla Bardram Johnbeck,

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Fredrik Björkling,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

    Current address: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Jacob Madsen,

    Affiliation: Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Michael Bzorek,

    Affiliation: Department of Pathology, Næstved Hospital, Næstved, Denmark

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  • Peter Buhl Jensen,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Liselotte Højgaard,

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Maxwell Sehested,

    Affiliation: TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark

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  • Andreas Kjær

    Affiliations: Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark

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  • Published: January 04, 2013
  • DOI: 10.1371/journal.pone.0053410

About the Authors

Mette Munk Jensen, Camilla Bardram Johnbeck, Liselotte Højgaard, Andreas Kjær
Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Mette Munk Jensen, Camilla Bardram Johnbeck, Jacob Madsen, Liselotte Højgaard, Andreas Kjær
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark
Kamille Dumong Erichsen, Fredrik Björkling, Peter Buhl Jensen, Maxwell Sehested
TopoTarget A/S, Symbion Science Park, Copenhagen, Denmark
Michael Bzorek
Department of Pathology, Næstved Hospital, Næstved, Denmark

Corresponding Author

Email: mettemj@sund.ku.dk

Competing Interests

The following co-authors have conflict of interests: Peter Buhl Jensen: Ownership Interests and Employment in Topotarget A/S. Maxwell Sehested: Ownership Interests and Employment in Topotarget A/S. Fredrik Björkling: Employment in Topotarget A/S. Kamille Dumong Erichsen: Employment in Topotarget A/S. All other authors have no conflict of interests. The authors do, to the best of their knowledge, not have any patent regarding APO866. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MMJ KDE FB PBJ LH MS AK. Performed the experiments: MMJ KDE CBJ JM MB. Analyzed the data: MMJ KDE AK. Wrote the paper: MMJ AK. Revised and approved the paper: KDE CBJ FB JM MB PBJ LH MS AK.