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Research Article

Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease

  • Jonathan D. Cherry,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Bin Liu,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jeffrey L. Frost,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cynthia A. Lemere,

    Affiliation: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jacqueline P. Williams,

    Affiliation: Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • John A. Olschowka,

    Affiliation: Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • M. Kerry O’Banion mail

    Kerry_Obanion@urmc.rochester.edu

    Affiliation: Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Published: December 31, 2012
  • DOI: 10.1371/journal.pone.0053275

About the Authors

Jonathan D. Cherry
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
Bin Liu, Jeffrey L. Frost, Cynthia A. Lemere
Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Jacqueline P. Williams
Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
John A. Olschowka, M. Kerry O’Banion
Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

Corresponding Author

Email: Kerry_Obanion@urmc.rochester.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDC CAL JPW JAO MKO. Performed the experiments: JDC BL JLF JPW MKO. Analyzed the data: JDC JAO MKO. Contributed reagents/materials/analysis tools: BL JLF CAL. Wrote the paper: JDC MKO.