About the Authors
- Ricardo A. García
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Debra J. Search
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- John A. Lupisella
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Jacek Ostrowski
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Bo Guan
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Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Jian Chen
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Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Wen-Pin Yang
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Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Amy Truong
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Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Aiqing He
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Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Rongan Zhang
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Mujing Yan
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Samuel E. Hellings
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Peter S. Gargalovic
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Carol S. Ryan
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Linda M. Watson
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Affiliation Pharmaceutical Compound Optimization: Discovery Toxicology, Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America
- Robert A. Langish
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Affiliation Pharmaceutical Compound Optimization: Discovery Analytical Sciences, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Petia A. Shipkova
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Affiliation Pharmaceutical Compound Optimization: Discovery Analytical Sciences, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Nancy L. Carson
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Joseph R. Taylor
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Affiliation Metabolic Diseases, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Richard Yang
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- George C. Psaltis
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Affiliation Veterinary Sciences, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Thomas W. Harrity
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Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- Jeffrey A. Robl
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Affiliation Discovery Chemistry, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
- David A. Gordon
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* E-mail: david.gordon@bms.com
Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
Competing Interests
The authors have the following interests: All authors are employees of Bristol-Myers Squibb, Co., the funder of this study. In addition, Bristol-Myers Squibb does have an interest in developing an inhibitor of 11Beta-Hydroxysteroid Dehydrogenase Type 1, the experimental gene described in the manuscript entitled; “11beta-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE−/− mice”. Patents protecting the intellectual property around the inhibitors are in process. However, no inhibitors, experimental or otherwise, were used in the studies described in this manuscript. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: RG DG JO JC PG WY TWH JR. Performed the experiments: DS JL BG AT AH MY CR LW RL PS NC JT RZ GP SH RY. Analyzed the data: RG JO PG DS JL BG AT AH MY CR LW RL PS NC JT RZ GP SH RY. Contributed reagents/materials/analysis tools: DS JL BG AT AH MY CR LW RL PS NC JT RZ GP SH. Wrote the paper: RG DG.