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Research Article

Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes

  • Camilla Luni,

    Affiliations: Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America, Sansum Diabetes Research Institute, Santa Barbara, California, United States of America

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  • Jamey D. Marth,

    Affiliation: Center for Nanomedicine, Sanford-Burnham Medical Research Institute and the Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

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  • Francis J. Doyle III mail

    frank.doyle@icb.ucsb.edu

    Affiliations: Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America, Sansum Diabetes Research Institute, Santa Barbara, California, United States of America

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pone.0053130

About the Authors

Camilla Luni, Francis J. Doyle III
Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America
Camilla Luni, Francis J. Doyle III
Sansum Diabetes Research Institute, Santa Barbara, California, United States of America
Jamey D. Marth
Center for Nanomedicine, Sanford-Burnham Medical Research Institute and the Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

Corresponding Author

Email: frank.doyle@icb.ucsb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CL JDM. Performed the experiments: CL. Analyzed the data: CL JDM FJD. Wrote the paper: CL JDM FJD.