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Research Article

Quinacrine Impairs Enterovirus 71 RNA Replication by Preventing Binding of Polypyrimidine-Tract Binding Protein with Internal Ribosome Entry Sites

  • Jianmin Wang,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

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  • Jiang Du,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

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  • Zhiqiang Wu,

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

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  • Qi Jin mail

    zdsys@vip.sina.com

    Affiliation: MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pone.0052954

About the Authors

Jianmin Wang, Jiang Du, Zhiqiang Wu, Qi Jin
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China

Corresponding Author

Email: zdsys@vip.sina.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMW JD ZQW QJ. Performed the experiments: JMW JD ZQW QJ. Analyzed the data: JMW JD ZQW QJ. Contributed reagents/materials/analysis tools: JMW JD ZQW QJ. Wrote the paper: JMW JD ZQW QJ.