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Research Article

Critical Roles of Myc-ODC Axis in the Cellular Transformation Induced by Myeloproliferative Neoplasm-Associated JAK2 V617F Mutant

  • Megumi Funakoshi-Tago mail,

    tago-mg@pha.keio.ac.jp (MF-T); ktago@jichi.ac.jp (KT)

    Affiliation: Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan

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  • Kazuya Sumi,

    Affiliation: Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan

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  • Tadashi Kasahara,

    Affiliation: Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan

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  • Kenji Tago mail

    tago-mg@pha.keio.ac.jp (MF-T); ktago@jichi.ac.jp (KT)

    Affiliation: Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Shimotsuke-shi, Japan

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  • Published: January 03, 2013
  • DOI: 10.1371/journal.pone.0052844

About the Authors

Megumi Funakoshi-Tago, Kazuya Sumi, Tadashi Kasahara
Department of Biochemistry, Faculty of Pharmacology, Keio University, Tokyo, Japan
Kenji Tago
Division of Structural Biochemistry, Department of Biochemistry, Jichi Medical University, Shimotsuke-shi, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MFT KT. Performed the experiments: MFT KS. Analyzed the data: MFT TK KT. Contributed reagents/materials/analysis tools: MFT KT. Wrote the paper: MFT KT.