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Research Article

Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity

  • Yoshiomi Kobayashi equal contributor,

    equal contributor Contributed equally to this work with: Yoshiomi Kobayashi, Yohei Okada

    Affiliations: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Yohei Okada equal contributor,

    equal contributor Contributed equally to this work with: Yoshiomi Kobayashi, Yohei Okada

    Affiliation: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

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  • Go Itakura,

    Affiliations: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Hiroki Iwai,

    Affiliations: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Soraya Nishimura,

    Affiliations: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Akimasa Yasuda,

    Affiliation: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

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  • Satoshi Nori,

    Affiliation: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

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  • Keigo Hikishima,

    Affiliations: Department of Physiology, School of Medicine, Keio University, Tokyo, Japan, Central Institute for Experimental Animals, Kanagawa, Japan

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  • Tsunehiko Konomi,

    Affiliations: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Kanehiro Fujiyoshi,

    Affiliation: Department of Orthopedic Surgery, National Hospital Organization Murayama Medical Center, Tokyo, Japan

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  • Osahiko Tsuji,

    Affiliation: Department of Orthopedic Surgery, Saitama Social Insurance Hospital, Saitama, Japan

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  • Yoshiaki Toyama,

    Affiliation: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

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  • Shinya Yamanaka,

    Affiliation: Center for iPS Cell Research and Application (CiRA), Kyoto, Japan

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  • Masaya Nakamura mail,

    masa@a8.keio.jp (MN); hidokano@a2.keio.jp (HO)

    Affiliation: Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

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  • Hideyuki Okano mail

    masa@a8.keio.jp (MN); hidokano@a2.keio.jp (HO)

    Affiliation: Department of Physiology, School of Medicine, Keio University, Tokyo, Japan

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pone.0052787

About the Authors

Yoshiomi Kobayashi, Yohei Okada, Go Itakura, Hiroki Iwai, Soraya Nishimura, Akimasa Yasuda, Satoshi Nori, Tsunehiko Konomi, Yoshiaki Toyama, Masaya Nakamura
Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
Yoshiomi Kobayashi, Go Itakura, Hiroki Iwai, Soraya Nishimura, Keigo Hikishima, Tsunehiko Konomi, Hideyuki Okano
Department of Physiology, School of Medicine, Keio University, Tokyo, Japan
Keigo Hikishima
Central Institute for Experimental Animals, Kanagawa, Japan
Kanehiro Fujiyoshi
Department of Orthopedic Surgery, National Hospital Organization Murayama Medical Center, Tokyo, Japan
Osahiko Tsuji
Department of Orthopedic Surgery, Saitama Social Insurance Hospital, Saitama, Japan
Shinya Yamanaka
Center for iPS Cell Research and Application (CiRA), Kyoto, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YK YO YT MN HO. Performed the experiments: YK YO HI S. Nishimura KH TK KF. Analyzed the data: YK HI S. Nishimura AY TK KF MN. Contributed reagents/materials/analysis tools: YK YO GI HI S. Nishimura AY S. Nori KH TK KF OT SY. Wrote the paper: YK KH MN HO.