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Research Article

Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

  • David S. Terman equal contributor mail,

    equal contributor Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

    dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

    Affiliation: Molecular Genetics Program, Jenomic, Carmel, California, United States of America

    These authors also contributed equally to this work.

    X
  • Benjamin L. Viglianti equal contributor,

    equal contributor Contributed equally to this work with: David S. Terman, Benjamin L. Viglianti

    Affiliation: Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Rahima Zennadi,

    Affiliation: Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Diane Fels,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Richard J. Boruta,

    Affiliation: Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Hong Yuan,

    Affiliation: Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Mathew R. Dreher,

    Affiliation: National Institutes of Health, Clinical Center, Diagnostic Radiology Department, Bethesda, Maryland, United States of America

    X
  • Gerald Grant,

    Affiliation: Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Zahid N. Rabbani,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Ejung Moon,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Lan Lan,

    Affiliation: Department of Biostatistics, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Joseph Eble,

    Affiliation: Department of Radiology, Mayo Clinic Foundation, Rochester, Minnesota, United States of America

    X
  • Yiting Cao,

    Affiliation: Department of Surgery, Division of Neurooncology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Brian Sorg,

    Affiliation: Cancer Diagnosis Program, National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Kathleen Ashcraft,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Greg Palmer,

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Marilyn J. Telen,

    Affiliation: Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Mark W. Dewhirst mail

    dst@sbcglobal.net (DST); mark.dewhirst@duke.edu (MWD)

    Affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America

    These authors also contributed equally to this work.

    X
  • Published: January 09, 2013
  • DOI: 10.1371/journal.pone.0052543

About the Authors

David S. Terman
Molecular Genetics Program, Jenomic, Carmel, California, United States of America
Benjamin L. Viglianti
Department of Radiology, University of Michigan, Ann Arbor, Michigan, United States of America
Rahima Zennadi, Marilyn J. Telen
Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina, United States of America
Diane Fels, Zahid N. Rabbani, Ejung Moon, Kathleen Ashcraft, Greg Palmer, Mark W. Dewhirst
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America
Richard J. Boruta
Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, United States of America
Hong Yuan
Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
Mathew R. Dreher
National Institutes of Health, Clinical Center, Diagnostic Radiology Department, Bethesda, Maryland, United States of America
Gerald Grant
Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, United States of America
Lan Lan
Department of Biostatistics, Duke University Medical Center, Durham, North Carolina, United States of America
Joseph Eble
Department of Radiology, Mayo Clinic Foundation, Rochester, Minnesota, United States of America
Yiting Cao
Department of Surgery, Division of Neurooncology, Duke University Medical Center, Durham, North Carolina, United States of America
Brian Sorg
Cancer Diagnosis Program, National Cancer Institute, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have read the journal's policy and have the following conflicts: DST is sole inventor of US patent 7,803,637 filed August 30, 2000, issued September 28, 2010. All other authors have no competing interests. Dr. David S. Terman is employed by Jenomic. This does not alter his adherence to all the PLOS ONE policies on sharing data and materials. Reovirus Dearing Type 3 was provided by Oncolytics Biotech Inc. (Calgary, Canada). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DST. Performed the experiments: DST BLV RZ HY MRD GG ZNR EM JE YC BS KA RJB DF. Analyzed the data: DST MWD MJT LL GP BLV RZ BS. Wrote the paper: DST MWD.