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Research Article

Selective Protection of Human Liver Tissue in TNF-Targeting of Cancers of the Liver by Transient Depletion of Adenosine Triphosphate

  • Timo Weiland,

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Kathrin Klein,

    Affiliation: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

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  • Martina Zimmermann,

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Tobias Speicher,

    Affiliation: Department of Biology, Institute of Cell Biology, ETH Zürich, Switzerland

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  • Sascha Venturelli,

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Alexander Berger,

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Heike Bantel,

    Affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

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  • Alfred Königsrainer,

    Affiliation: Department of General, Visceral & Transplant Surgery, University Hospital, Tuebingen, Germany

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  • Martin Schenk,

    Affiliation: Department of General, Visceral & Transplant Surgery, University Hospital, Tuebingen, Germany

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  • Thomas S. Weiss,

    Affiliation: Center for Liver Cell Research, University Hospital, Regensburg, Germany

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  • Albrecht Wendel,

    Affiliation: Interfaculty Center for Pharmacogenomics and Drug Research (ICEPHA), University of Tuebingen, Germany

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  • Matthias Schwab,

    Affiliations: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Hospital, Tuebingen, Germany

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  • Michael Bitzer,

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Ulrich M. Lauer mail

    ulrich.lauer@uni-tuebingen.de

    Affiliation: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany

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  • Published: December 18, 2012
  • DOI: 10.1371/journal.pone.0052496

About the Authors

Timo Weiland, Martina Zimmermann, Sascha Venturelli, Alexander Berger, Michael Bitzer, Ulrich M. Lauer
Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany
Kathrin Klein, Matthias Schwab
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
Tobias Speicher
Department of Biology, Institute of Cell Biology, ETH Zürich, Switzerland
Heike Bantel
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
Alfred Königsrainer, Martin Schenk
Department of General, Visceral & Transplant Surgery, University Hospital, Tuebingen, Germany
Thomas S. Weiss
Center for Liver Cell Research, University Hospital, Regensburg, Germany
Albrecht Wendel
Interfaculty Center for Pharmacogenomics and Drug Research (ICEPHA), University of Tuebingen, Germany
Matthias Schwab
Department of Clinical Pharmacology, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University Hospital, Tuebingen, Germany

Corresponding Author

Email: ulrich.lauer@uni-tuebingen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TW MZ AW UML. Performed the experiments: TW KK MZ HB SV AB. Analyzed the data: TW KK SV AB HB. Contributed reagents/materials/analysis tools: TSW AK M. Schenk. Wrote the paper: TW AW M. Schwab ULM. Critical Revision: AW M. Schwab AK M. Schenk MB. Data interpretation and support: TS. Study supervision and support: MB.