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Research Article

A Common Polymorphism near the ESR1 Gene Is Associated with Risk of Breast Cancer: Evidence from a Case-Control Study and a Meta-Analysis

  • Hui Guo equal contributor,

    equal contributor Contributed equally to this work with: Hui Guo, Jie Ming

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Jie Ming equal contributor,

    equal contributor Contributed equally to this work with: Hui Guo, Jie Ming

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Chunping Liu,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Zhi Li,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Ning Zhang,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Hongtao Cheng,

    Affiliation: Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, People's Republic of China

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  • Wei Wang,

    Affiliation: Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, People's Republic of China

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  • Wei Shi,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Na Shen,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Qunzi Zhao,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Dapeng Li,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Pengfei Yi,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Longqiang Wang,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Rui Wang,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Yue Xin,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Xiangwang Zhao,

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Xiu Nie mail,

    huangtaowh@gmail.com (TH); niexiuyishi@126.com (XN)

    Affiliation: Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Tao Huang mail

    huangtaowh@gmail.com (TH); niexiuyishi@126.com (XN)

    Affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China

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  • Published: December 18, 2012
  • DOI: 10.1371/journal.pone.0052445

About the Authors

Hui Guo, Jie Ming, Chunping Liu, Zhi Li, Ning Zhang, Wei Shi, Na Shen, Qunzi Zhao, Dapeng Li, Pengfei Yi, Longqiang Wang, Rui Wang, Yue Xin, Xiangwang Zhao, Tao Huang
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Xiu Nie
Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China
Hongtao Cheng, Wei Wang
Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, People's Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TH HG JM. Performed the experiments: HG WS WW QZ PY RW YX XZ. Analyzed the data: HG JM. Contributed reagents/materials/analysis tools: XN CL ZL HC NZ NS DL LW. Wrote the paper: HG JM XN TH.