Capsule Influences the Deposition of Critical Complement C3 Levels Required for the Killing of Burkholderia pseudomallei via NADPH-Oxidase Induction by Human Neutrophils

Michael E. Woodman; Randall G. Worth; R. Mark Wooten

doi:10.1371/journal.pone.0052276

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Open Access

Peer-reviewed

Research Article

Capsule Influences the Deposition of Critical Complement C3 Levels Required for the Killing of Burkholderia pseudomallei via NADPH-Oxidase Induction by Human Neutrophils

Michael E. Woodman,

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America
⨯
Randall G. Worth,

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America
⨯
R. Mark Wooten

* E-mail: R.Mark.Wooten@utoledo.edu

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America
⨯

Capsule Influences the Deposition of Critical Complement C3 Levels Required for the Killing of Burkholderia pseudomallei via NADPH-Oxidase Induction by Human Neutrophils

Michael E. Woodman,
Randall G. Worth,
R. Mark Wooten

Published: December 14, 2012
https://doi.org/10.1371/journal.pone.0052276

About the Authors

Michael E. Woodman

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

Randall G. Worth

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

R. Mark Wooten

* E-mail: R.Mark.Wooten@utoledo.edu

Affiliation Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MEW RGW RMW. Performed the experiments: MEW. Analyzed the data: MEW RMW. Contributed reagents/materials/analysis tools: RMW. Wrote the paper: MEW RMW.

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Neutrophils
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Respiratory infections
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Melioidosis
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Opsonization
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Burkholderia pseudomallei
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Complement system
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Respiratory burst
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Flow cytometry
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