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Research Article

Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

  • Madhuri S. Salker,

    Affiliations: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • Jaya Nautiyal,

    Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • Jennifer H. Steel,

    Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • Zoe Webster,

    Affiliation: Embryonic Stem Cell Facility, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • Sandra Šućurović,

    Affiliations: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom, Department of Physiology and Immunology, Medical School, University of Rijeka, Rijeka, Croatia

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  • Marilena Nicou,

    Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • Yogesh Singh,

    Affiliation: Department of Infection and Immunity, The Royal Veterinary College, Royal College Street, London, United Kingdom

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  • Emma S. Lucas,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Keisuke Murakami,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Yi-Wah Chan,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Sean James,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Yazan Abdallah,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Mark Christian,

    Affiliation: Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom

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  • B. Anne Croy,

    Affiliation: Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada

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  • Biserka Mulac-Jericevic,

    Affiliation: Department of Physiology and Immunology, Medical School, University of Rijeka, Rijeka, Croatia

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  • Siobhan Quenby,

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Jan J. Brosens mail

    J.J.Brosens@warwick.ac.uk

    Affiliation: Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pone.0052252

About the Authors

Madhuri S. Salker, Sandra Šućurović, Emma S. Lucas, Keisuke Murakami, Yi-Wah Chan, Sean James, Yazan Abdallah, Siobhan Quenby, Jan J. Brosens
Division of Reproductive Health, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospital, Coventry, United Kingdom
Madhuri S. Salker, Jaya Nautiyal, Jennifer H. Steel, Marilena Nicou, Mark Christian
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom
Zoe Webster
Embryonic Stem Cell Facility, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, United Kingdom
Sandra Šućurović, Biserka Mulac-Jericevic
Department of Physiology and Immunology, Medical School, University of Rijeka, Rijeka, Croatia
Yogesh Singh
Department of Infection and Immunity, The Royal Veterinary College, Royal College Street, London, United Kingdom
B. Anne Croy
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada

Corresponding Author

Email: J.J.Brosens@warwick.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MSS JJB. Performed the experiments: MSS JN JHS ZW SS MN YS KM SJ MC. Analyzed the data: MSS MN YWC JHS YS. Contributed reagents/materials/analysis tools: YA SQ JJB. Wrote the paper: MSS ESL JJB BAC BM.