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Research Article

Comparative Analysis of DNA Nanoparticles and AAVs for Ocular Gene Delivery

  • Zongchao Han,

    Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Shannon M. Conley,

    Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Rasha Makkia,

    Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Junjing Guo,

    Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Mark J. Cooper,

    Affiliation: Copernicus Therapeutics, Inc., Cleveland, Ohio, United States of America

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  • Muna I. Naash mail

    Muna-Naash@ouhsc.edu

    Affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

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  • Published: December 18, 2012
  • DOI: 10.1371/journal.pone.0052189

About the Authors

Zongchao Han, Shannon M. Conley, Rasha Makkia, Junjing Guo, Muna I. Naash
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
Mark J. Cooper
Copernicus Therapeutics, Inc., Cleveland, Ohio, United States of America

Corresponding Author

Email: Muna-Naash@ouhsc.edu

Competing Interests

MJC is an employee of Copernicus Therapeutics and owns stock and stock options in the company. There are issued and pending patents covering DNA nanoparticle compositions and their use as therapy for ocular disease. Nanoparticles are in development at Copernicus Therapeutics and there are no current marketed products. This information does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: ZH MIN. Performed the experiments: ZH SMC RM JG MIN. Analyzed the data: ZH SMC MIN. Contributed reagents/materials/analysis tools: MJC MIN. Wrote the paper: ZH SMC MJC MIN.