About the Authors

Patricio S. La Rosa

Affiliation Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

J. Paul Brooks

Affiliation Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

Elena Deych

Affiliation Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

Edward L. Boone

Affiliation Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

David J. Edwards

Affiliation Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

Qin Wang

Affiliation Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

Erica Sodergren

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

George Weinstock

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America

William D. Shannon

wshannon@wustl.edu

Affiliation Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GW ES. Performed the experiments: GW ES. Analyzed the data: PSL ED WDS. Wrote the paper: PSL WDS. Design Statistical Methods: PSL JPB ELB DJE QW WDS. Design Software: PSL ED WDS.