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Research Article

A Polymeric Nanomedicine Diminishes Inflammatory Events in Renal Tubular Cells

  • Álvaro C. Ucero equal contributor,

    equal contributor Contributed equally to this work with: Álvaro C. Ucero, Sergio Berzal

    Affiliation: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain

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  • Sergio Berzal equal contributor,

    equal contributor Contributed equally to this work with: Álvaro C. Ucero, Sergio Berzal

    Affiliation: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain

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  • Carlos Ocaña-Salceda,

    Affiliation: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain

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  • Mónica Sancho,

    Affiliation: Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain

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  • Mar Orzáez,

    Affiliation: Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain

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  • Angel Messeguer,

    Affiliation: Department of Chemical and Biomolecular Nanotechnology, Institut de Química Avançada de Catalunya, Barcelona, Spain

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  • Marta Ruiz-Ortega,

    Affiliations: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain, Cellular Biology in Renal Diseases Laboratory, Universidad Autónoma de Madrid, Madrid, Spain

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  • Jesús Egido,

    Affiliations: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain, Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Madrid, Spain

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  • María J. Vicent,

    Affiliation: Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain

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  • Alberto Ortiz,

    Affiliations: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain, Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Madrid, Spain

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  • Adrián M. Ramos mail

    amramos@fjd.es

    Affiliation: Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain

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  • Published: January 02, 2013
  • DOI: 10.1371/journal.pone.0051992

About the Authors

Álvaro C. Ucero, Sergio Berzal, Carlos Ocaña-Salceda, Marta Ruiz-Ortega, Jesús Egido, Alberto Ortiz, Adrián M. Ramos
Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain
Mónica Sancho, Mar Orzáez, María J. Vicent
Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain
Angel Messeguer
Department of Chemical and Biomolecular Nanotechnology, Institut de Química Avançada de Catalunya, Barcelona, Spain
Marta Ruiz-Ortega
Cellular Biology in Renal Diseases Laboratory, Universidad Autónoma de Madrid, Madrid, Spain
Jesús Egido, Alberto Ortiz
Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Madrid, Spain

Corresponding Author

Email: amramos@fjd.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACU SB AO AMR. Performed the experiments: ACU SB CO MS. Analyzed the data: ACU SB. Contributed reagents/materials/analysis tools: MO AM MJV MRO JE AO. Wrote the paper: JE AO AMR. Conceptual design: AMR. Direction of the experimental work: AMR. Analysis of the experimental work: AMR.