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Research Article

Pilot Investigation of the Circadian Plasma Melatonin Rhythm across the Menstrual Cycle in a Small Group of Women with Premenstrual Dysphoric Disorder

  • Ari Shechter,

    Affiliation: Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada

    Current address: New York Obesity Nutrition Research Center, St. Luke’s-Roosevelt Hospital, New York, New York, United States of America

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  • Paul Lespérance,

    Affiliation: Department of Psychiatry, Centre Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Québec, Canada

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  • N. M. K. Ng Ying Kin,

    Affiliation: Clinical Research Division, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada

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  • Diane B. Boivin mail

    diane.boivin@douglas.mcgill.ca

    Affiliation: Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada

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  • Published: December 19, 2012
  • DOI: 10.1371/journal.pone.0051929

About the Authors

Ari Shechter, Diane B. Boivin
Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada
Paul Lespérance
Department of Psychiatry, Centre Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Québec, Canada
N. M. K. Ng Ying Kin
Clinical Research Division, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada

Corresponding Author

Email: diane.boivin@douglas.mcgill.ca

Competing Interests

DBB is Founder/CEO of Alpha Logik Consultants, Inc. This disclosed interest has no relation to the work presented in the current manuscript. The remaining authors have declared that no competing interests exist. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DBB. Performed the experiments: AS. Analyzed the data: AS. Contributed reagents/materials/analysis tools: NMK PL. Wrote the paper: AS DBB. Conducted psychiatric evaluations of patients for inclusion in study: PL. Conducted melatonin assays: NMK. Revised manuscript critically for important intellectual content: AS PL NMK DBB. Provided final approval of the submitted manuscript: AS PL NMK DBB.