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Research Article

Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function

  • Thierry N’Tumba-Byn,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Delphine Moison,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Marlène Lacroix,

    Affiliation: INRA, UMR1331, TOXALIM, Toulouse, France

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  • Charlotte Lecureuil,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Laëtitia Lesage,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Sophie M. Prud’homme,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Stéphanie Pozzi-Gaudin,

    Affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

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  • René Frydman,

    Affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

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  • Alexandra Benachi,

    Affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

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  • Gabriel Livera,

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Virginie Rouiller-Fabre equal contributor,

    equal contributor Contributed equally to this work with: Virginie Rouiller-Fabre, René Habert

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • René Habert equal contributor mail

    equal contributor Contributed equally to this work with: Virginie Rouiller-Fabre, René Habert

    rene.habert@cea.fr

    Affiliations: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France, CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France, INSERM, Unité 967, Fontenay aux Roses, France

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  • Published: December 17, 2012
  • DOI: 10.1371/journal.pone.0051579

About the Authors

Thierry N’Tumba-Byn, Delphine Moison, Charlotte Lecureuil, Laëtitia Lesage, Sophie M. Prud’homme, Gabriel Livera, Virginie Rouiller-Fabre, René Habert
Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation, Fontenay-aux-Roses, France
Thierry N’Tumba-Byn, Delphine Moison, Charlotte Lecureuil, Laëtitia Lesage, Sophie M. Prud’homme, Gabriel Livera, Virginie Rouiller-Fabre, René Habert
CEA, DSV, iRCM, SCSR, LDG, Fontenay-aux-Roses, France
Thierry N’Tumba-Byn, Delphine Moison, Charlotte Lecureuil, Laëtitia Lesage, Sophie M. Prud’homme, Gabriel Livera, Virginie Rouiller-Fabre, René Habert
INSERM, Unité 967, Fontenay aux Roses, France
Marlène Lacroix
INRA, UMR1331, TOXALIM, Toulouse, France
Stéphanie Pozzi-Gaudin, René Frydman, Alexandra Benachi
Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital A. Béclère, Université Paris Sud, Clamart, France

Corresponding Author

Email: rene.habert@cea.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RH VRF. Performed the experiments: TNTB DM ML CL LL SMP. Analyzed the data: RH GL VRF. Contributed reagents/materials/analysis tools: SPG RF AB. Wrote the paper: RH TNTB.