Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

Irina Margine; Luis Martinez-Gil; Yi-ying Chou; Florian Krammer

doi:10.1371/journal.pone.0051559

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Peer-reviewed

Research Article

Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

Irina Margine,

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Luis Martinez-Gil,

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Yi-ying Chou,

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Florian Krammer

* E-mail: florian.krammer@mssm.edu

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯

Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

Irina Margine,
Luis Martinez-Gil,
Yi-ying Chou,
Florian Krammer

Published: December 7, 2012
https://doi.org/10.1371/journal.pone.0051559

About the Authors

Irina Margine

Affiliations Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Luis Martinez-Gil

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

Yi-ying Chou

Florian Krammer

* E-mail: florian.krammer@mssm.edu

Affiliation Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM FK. Performed the experiments: IM LM YC FK. Analyzed the data: IM FK. Wrote the paper: IM FK.

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Viral vaccines
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Antibodies
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Enzyme-linked immunoassays
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Influenza viruses
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Vaccination and immunization
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Influenza
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Antigens
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Immune response
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