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Research Article

Reduction of [11C](+)3-MPB Binding in Brain of Chronic Fatigue Syndrome with Serum Autoantibody against Muscarinic Cholinergic Receptor

  • Shigeyuki Yamamoto,

    Affiliations: Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan, Central Research Laboratory, Hamamatsu Photonics KK, Hamakita, Shizuoka, Japan

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  • Yasuomi Ouchi,

    Affiliation: Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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  • Daisaku Nakatsuka,

    Affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan

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  • Tsuyoshi Tahara,

    Affiliation: RIKEN Center for Molecular Imaging Science (CMIS), Kobe, Hyogo, Japan

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  • Kei Mizuno,

    Affiliation: RIKEN Center for Molecular Imaging Science (CMIS), Kobe, Hyogo, Japan

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  • Seiki Tajima,

    Affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan

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  • Hirotaka Onoe,

    Affiliation: RIKEN Center for Molecular Imaging Science (CMIS), Kobe, Hyogo, Japan

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  • Etsuji Yoshikawa,

    Affiliation: Central Research Laboratory, Hamamatsu Photonics KK, Hamakita, Shizuoka, Japan

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  • Hideo Tsukada,

    Affiliation: Central Research Laboratory, Hamamatsu Photonics KK, Hamakita, Shizuoka, Japan

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  • Masao Iwase,

    Affiliation: Psychiatry, Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan

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  • Kouzi Yamaguti,

    Affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan

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  • Hirohiko Kuratsune,

    Affiliation: Department of Health Sciences, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Japan

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  • Yasuyoshi Watanabe mail

    yywata@riken.jp

    Affiliations: Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan, RIKEN Center for Molecular Imaging Science (CMIS), Kobe, Hyogo, Japan

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  • Published: December 11, 2012
  • DOI: 10.1371/journal.pone.0051515

About the Authors

Shigeyuki Yamamoto, Daisaku Nakatsuka, Seiki Tajima, Kouzi Yamaguti, Yasuyoshi Watanabe
Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan
Shigeyuki Yamamoto, Etsuji Yoshikawa, Hideo Tsukada
Central Research Laboratory, Hamamatsu Photonics KK, Hamakita, Shizuoka, Japan
Yasuomi Ouchi
Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
Tsuyoshi Tahara, Kei Mizuno, Hirotaka Onoe, Yasuyoshi Watanabe
RIKEN Center for Molecular Imaging Science (CMIS), Kobe, Hyogo, Japan
Masao Iwase
Psychiatry, Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan
Hirohiko Kuratsune
Department of Health Sciences, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Japan

Corresponding Author

Email: yywata@riken.jp

Competing Interests

The authors have read the journal’s policy and have the following conflicts: SY, EY and HT are employees of Hamamatsu Photonics KK. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YW. Performed the experiments: SY YO DN TT ST EY HT MI KY HK. Analyzed the data: SY TT KM ST EY. Wrote the paper: SY YO KM HO YW.