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Research Article

Cubozoan Venom-Induced Cardiovascular Collapse Is Caused by Hyperkalemia and Prevented by Zinc Gluconate in Mice

  • Angel A. Yanagihara mail,

    angel@pbrc.hawaii.edu

    Affiliations: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America, Békésy Laboratory of Neurobiology, Pacific Bioscience Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Ralph V. Shohet

    Affiliation: Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

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  • Published: December 12, 2012
  • DOI: 10.1371/journal.pone.0051368

About the Authors

Angel A. Yanagihara
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Angel A. Yanagihara
Békésy Laboratory of Neurobiology, Pacific Bioscience Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America
Ralph V. Shohet
Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States of America

Corresponding Author

Email: angel@pbrc.hawaii.edu

Competing Interests

AAY has a provisional patent for treatment of syndromes associated with pore-forming toxins, U.S. Patent Office #61245238. RVS is listed as a contributing party to this document. The filing of a provisional patent application for treatment of syndromes associated with pore-forming toxins, U.S. Patent Office #61245238 by the University of Hawaii Office of Technology Transfer and Economic Development with RVS is listed as a contributing party does not alter the adherence of the authors (AAY and RVS) to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AAY RVS. Performed the experiments: AAY. Analyzed the data: AAY RVS. Contributed reagents/materials/analysis tools: AAY. Wrote the paper: AAY RVS.