Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

Gene P. Ables; Carmen E. Perrone; David Orentreich; Norman Orentreich

doi:10.1371/journal.pone.0051357

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Peer-reviewed

Research Article

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

Gene P. Ables ,

* E-mail: gables@orentreich.org

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America
⨯
Carmen E. Perrone,

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America
⨯
David Orentreich,

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America
⨯
Norman Orentreich

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America
⨯

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

Gene P. Ables,
Carmen E. Perrone,
David Orentreich,
Norman Orentreich

Published: December 7, 2012
https://doi.org/10.1371/journal.pone.0051357

About the Authors

Gene P. Ables

* E-mail: gables@orentreich.org

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America

Carmen E. Perrone

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America

David Orentreich

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America

Norman Orentreich

Affiliation Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GPA CEP. Performed the experiments: GPA. Analyzed the data: GPA. Contributed reagents/materials/analysis tools: GPA. Wrote the paper: GPA CEP DO NO.

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Insulin
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Diet
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Mouse models
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Body weight
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Glucose
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Insulin resistance
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Gene expression
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Diet and type 2 diabetes
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