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Research Article

E-Peptides Control Bioavailability of IGF-1

  • Marianne Smedegaard Hede equal contributor,

    equal contributor Contributed equally to this work with: Marianne Smedegaard Hede, Ekaterina Salimova

    Affiliation: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy

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  • Ekaterina Salimova equal contributor mail,

    equal contributor Contributed equally to this work with: Marianne Smedegaard Hede, Ekaterina Salimova

    ekaterina.salimova@monash.edu (ES); nadia.rosenthal@monash.edu (NR)

    Affiliations: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy, Australian Regenerative Medicine Institute, EMBL Australia/Monash University, Melbourne, Australia

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  • Agnieszka Piszczek,

    Affiliation: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy

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  • Emarald Perlas,

    Affiliation: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy

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  • Nadine Winn,

    Affiliation: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy

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  • Tommaso Nastasi,

    Affiliation: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy

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  • Nadia Rosenthal mail

    ekaterina.salimova@monash.edu (ES); nadia.rosenthal@monash.edu (NR)

    Affiliations: European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy, Australian Regenerative Medicine Institute, EMBL Australia/Monash University, Melbourne, Australia, National Heart and Lung Institute, Imperial College London, London, United Kingdom

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  • Published: December 10, 2012
  • DOI: 10.1371/journal.pone.0051152

About the Authors

Marianne Smedegaard Hede, Ekaterina Salimova, Agnieszka Piszczek, Emarald Perlas, Nadine Winn, Tommaso Nastasi, Nadia Rosenthal
European Molecular Biology Laboratory (EMBL)-Mouse Biology Unit, Monterotondo, Rome, Italy
Ekaterina Salimova, Nadia Rosenthal
Australian Regenerative Medicine Institute, EMBL Australia/Monash University, Melbourne, Australia
Nadia Rosenthal
National Heart and Lung Institute, Imperial College London, London, United Kingdom

Corresponding Authors

Competing Interests

As this work was partially supported by a sponsored research agreement with Novartis, the authors declare that the involvement of this commercial funder does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MSH ES. Performed the experiments: MSH ES AP EP NW TN. Analyzed the data: MSH ES AP NW. Wrote the paper: MSH ES NR.