About the Authors

Dongmei Wu

dongmeiwu@bellsouth.net

Affiliations Department of Research, Mount Sinai Medical Center, Miami Beach, Florida, United States of America, Department of BIN Fusion Technology, WCU program, Chonbuk National University, Jeollabuk-do, Korea

Xinchun Lin

Affiliation Department of Research, Mount Sinai Medical Center, Miami Beach, Florida, United States of America

Christian Bernloehr

Affiliation Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach, Germany

Tobias Hildebrandt

Affiliation Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach, Germany

Henri Doods

Affiliation Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach, Germany

Competing Interests

This work was supported by Boehringer Ingelheim Pharma KG, Biberach, Germany; and in part by the World Class University Program (R31-20029) funded by the Ministry of Education, Science and Technology, Republic of Korea. Dr. Wu was a former employee (1996-1999) and consultant of BI and has continued to collaborate with Boehringer Ingelheim Pharma KG. BI-113823 is being developed by Boehringer Ingelheim Pharma. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. This is a collaborative work between Dr. Wu’s laboratory and BI. Christian Bernloehr, Tobias Hildebrandt, and Henri Doods are employed by Boehringer Ingelheim Pharma GmbH & Co.KG. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DW HD. Performed the experiments: XL CB TH. Analyzed the data: DW XL CB TH. Wrote the paper: DW HD.