# wombat urls ß PLOS ONE: Release of Dengue Virus Genome Induced by a Peptide Inhibitor
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Research Article

Release of Dengue Virus Genome Induced by a Peptide Inhibitor

  • Shee-Mei Lok equal contributor,

    equal contributor Contributed equally to this work with: Shee-Mei Lok, Joshua M. Costin

    Affiliations: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, Emerging Infectious Diseases, Duke–NUS, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

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  • Joshua M. Costin equal contributor,

    equal contributor Contributed equally to this work with: Shee-Mei Lok, Joshua M. Costin

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Yancey M. Hrobowski,

    Affiliations: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America, Department of Microbiology and Immunology and Graduate Program in Cellular and Molecular Biology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

    Current address: Operations and Tactics Division, Center for Naval Analyses, Alexandria, Virginia, United States of America

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  • Andrew R. Hoffmann,

    Affiliation: Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

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  • Dawne K. Rowe,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Petra Kukkaro,

    Affiliation: Emerging Infectious Diseases, Duke–NUS, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

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  • Heather Holdaway,

    Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

    Current address: Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Paul Chipman,

    Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

    Current address: Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America

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  • Krystal A. Fontaine,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

    Current address: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Michael R. Holbrook,

    Affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

    Current address: NIAID Integrated Research Facility, Ft. Detrick, Frederick, Maryland, United States of America

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  • Robert F. Garry,

    Affiliation: Department of Microbiology and Immunology and Graduate Program in Cellular and Molecular Biology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

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  • Victor Kostyuchenko,

    Affiliation: Emerging Infectious Diseases, Duke–NUS, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

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  • William C. Wimley,

    Affiliation: Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

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  • Sharon Isern,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Michael G. Rossmann,

    Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

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  • Scott F. Michael mail

    smichael@fgcu.edu

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Published: November 30, 2012
  • DOI: 10.1371/journal.pone.0050995

About the Authors

Shee-Mei Lok, Heather Holdaway, Paul Chipman, Michael G. Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
Joshua M. Costin, Yancey M. Hrobowski, Dawne K. Rowe, Krystal A. Fontaine, Sharon Isern, Scott F. Michael
Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America
Yancey M. Hrobowski, Robert F. Garry
Department of Microbiology and Immunology and Graduate Program in Cellular and Molecular Biology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
Andrew R. Hoffmann, William C. Wimley
Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
Michael R. Holbrook
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
Shee-Mei Lok, Petra Kukkaro, Victor Kostyuchenko
Emerging Infectious Diseases, Duke–NUS, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

Corresponding Author

Email: smichael@fgcu.edu

Competing Interests

Tulane University has applied for patents covering the peptide described in this work with RFG and SFM as inventors (7,416,733 issued 8/26/2008, 7,854,937 issued 12/21/2010, application 20110130328 filed 8/22/2008). This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JMC SML WCW MGR SI RFG SFM. Performed the experiments: SML VK MGR HH PC PK JMC YMH MRH DKR KAF SI ARH. Analyzed the data: JMC SML WCW MGR SI RFG SFM. Wrote the paper: SML JMC WCW MGR SFM.