RNA-Seq vs Dual- and Single-Channel Microarray Data: Sensitivity Analysis for Differential Expression and Clustering

Alina Sîrbu; Gráinne Kerr; Martin Crane; Heather J. Ruskin

doi:10.1371/journal.pone.0050986

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Open Access

Peer-reviewed

Research Article

RNA-Seq vs Dual- and Single-Channel Microarray Data: Sensitivity Analysis for Differential Expression and Clustering

Alina Sîrbu ,

* E-mail: asirbu@computing.dcu.ie

Affiliations Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland, Institute for Scientific Interchange Foundation, Turin, Italy
⨯
Gráinne Kerr,

Affiliation Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany
⨯
Martin Crane,

Affiliation Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland
⨯
Heather J. Ruskin

Affiliation Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland
⨯

RNA-Seq vs Dual- and Single-Channel Microarray Data: Sensitivity Analysis for Differential Expression and Clustering

Alina Sîrbu,
Gráinne Kerr,
Martin Crane,
Heather J. Ruskin

Published: December 10, 2012
https://doi.org/10.1371/journal.pone.0050986

About the Authors

Alina Sîrbu

* E-mail: asirbu@computing.dcu.ie

Affiliations Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland, Institute for Scientific Interchange Foundation, Turin, Italy

Gráinne Kerr

Affiliation Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany

Martin Crane

Affiliation Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland

Heather J. Ruskin

Affiliation Centre for Scientific Computing and Complex Systems Modelling, Dublin City University, Dublin, Ireland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS GK HJR. Performed the experiments: AS. Analyzed the data: AS GK. Wrote the paper: AS GK HJR MC. Provided additional background on microarray technologies: MC.

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Microarrays
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Gene expression
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Drosophila melanogaster
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Embryo development
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Next-generation sequencing
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RNA sequencing
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Clustering algorithms
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Invertebrate genomics
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