About the Authors

Shanker Swaminathan

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Matthew J. Huentelman

Affiliations Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, The Arizona Alzheimer's Consortium, Phoenix, Arizona, United States of America

Jason J. Corneveaux

Affiliations Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, The Arizona Alzheimer's Consortium, Phoenix, Arizona, United States of America

Amanda J. Myers

Affiliations Departments of Psychiatry and Behavioral Sciences, and Human Genetics and Genomics, University of Miami, Miller School of Medicine, Miami, Florida, United States of America, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute, Tampa, Florida, United States of America

Kelley M. Faber

Affiliation Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Tatiana Foroud

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Richard Mayeux

Affiliation The Gertrude H. Sergievsky Center, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

Li Shen

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Sungeun Kim

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Mari Turk

Affiliations Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, The Arizona Alzheimer's Consortium, Phoenix, Arizona, United States of America

John Hardy

Affiliation Department of Molecular Neuroscience and Reta Lila Research Laboratories, University College London Institute of Neurology, London, United Kingdom

Eric M. Reiman

Affiliations Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, The Arizona Alzheimer's Consortium, Phoenix, Arizona, United States of America, Banner Alzheimer’s Institute, Phoenix, Arizona, United States of America

Andrew J. Saykin

asaykin@iupui.edu

Affiliations Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Competing Interests

Genotyping of the TGen cohort was supported by Kronos Science. This study was partly funded by Glaxo Smith Kline. Data collection and sharing for the Alzheimer's Disease Neuroimaging Initiative (ADNI) project was funded by the ADNI (NIH U01AG024904; RC2AG036535). ADNI is funded by the NIA, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott; Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffman-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SS MJH LS AS. Performed the experiments: SS MJH JJC AJM KMF TF RM LS MT JH EMR AS. Analyzed the data: SS MJH LS SK AS. Contributed reagents/materials/analysis tools: MJH JJC AJM KMF AS. Wrote the paper: SS MJH JJC AJM KMF TF RM LS SK MT JH EMR AS.