Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation In Vitro but Not Increased Replication and Pathogenicity in Chickens and Ducks

Shin-Hee Kim; Sa Xiao; Heather Shive; Peter L. Collins; Siba K. Samal

doi:10.1371/journal.pone.0050598

Loading metrics

Open Access

Peer-reviewed

Research Article

Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation In Vitro but Not Increased Replication and Pathogenicity in Chickens and Ducks

Shin-Hee Kim,

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Sa Xiao,

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯
Heather Shive,

Affiliation Experimental Transplantation and Immunology Branch, National Cancer Institute/National Institute of Health, Bethesda, Maryland, United States of America
⨯
Peter L. Collins,

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
⨯
Siba K. Samal

* E-mail: ssamal@umd.edu

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
⨯

Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation In Vitro but Not Increased Replication and Pathogenicity in Chickens and Ducks

Shin-Hee Kim,
Sa Xiao,
Heather Shive,
Peter L. Collins,
Siba K. Samal

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0050598

About the Authors

Shin-Hee Kim

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

Sa Xiao

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

Heather Shive

Affiliation Experimental Transplantation and Immunology Branch, National Cancer Institute/National Institute of Health, Bethesda, Maryland, United States of America

Peter L. Collins

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

Siba K. Samal

* E-mail: ssamal@umd.edu

Affiliation Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHK PLC SKS. Performed the experiments: SHK SX. Analyzed the data: SHK SX HS. Contributed reagents/materials/analysis tools: PLC SKS. Wrote the paper: SHK PLC SKS.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Chickens
Is the Subject Area "Chickens" applicable to this article?

Thanks for your feedback.
Protein cleavage
Is the Subject Area "Protein cleavage" applicable to this article?

Thanks for your feedback.
Proteases
Is the Subject Area "Proteases" applicable to this article?

Thanks for your feedback.
Pathogenesis
Is the Subject Area "Pathogenesis" applicable to this article?

Thanks for your feedback.
Ducks
Is the Subject Area "Ducks" applicable to this article?

Thanks for your feedback.
Trachea
Is the Subject Area "Trachea" applicable to this article?

Thanks for your feedback.
Chicken eggs
Is the Subject Area "Chicken eggs" applicable to this article?

Thanks for your feedback.