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Research Article

Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting

  • Juliana M. Chan,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Molecular Engineering Laboratory, Agency for Science, Technology and Research, Singapore, Singapore

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  • Ioannis K. Zervantonakis,

    Affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Tharathorn Rimchala,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • William J. Polacheck,

    Affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jordan Whisler,

    Affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Roger D. Kamm mail

    rdkamm@mit.edu

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: December 04, 2012
  • DOI: 10.1371/journal.pone.0050582

About the Authors

Juliana M. Chan, Tharathorn Rimchala, Roger D. Kamm
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Juliana M. Chan
Molecular Engineering Laboratory, Agency for Science, Technology and Research, Singapore, Singapore
Ioannis K. Zervantonakis, William J. Polacheck, Jordan Whisler, Roger D. Kamm
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: rdkamm@mit.edu

Competing Interests

The authors have the following interests: this research was funded in part by a L'Oreal-UNESCO For Women In Science Fellowship. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JMC RDK. Performed the experiments: JMC IKZ TR WP JW. Analyzed the data: JMC IKZ TR WP JW. Contributed reagents/materials/analysis tools: JMC JMC IKZ TR WP JW. Wrote the paper: JMC RDK.